동물분자생체공학연구소 주관 초청강연 54
연사 : 홍석호 교수 (강원대학교)
제목 : 폐 오가노이드 개발 및 활용
일시 : 2024년 3월 26일 화요일 오후 1시 30분
장소 : 생명과학관 서관 437호
초록
Recently, the development of three-dimensional alveolar organoid (AO) system using human pluripotent stem cells (hPSCs) has attracted great attention compared to conventional 2D monolayer alveolar epithelial cell cultures for studying early alveoli development, modeling pulmonary diseases, screening for novel drugs and evaluation of viral infection and toxic materials. Although AO technology is consistently and rapidly being developed, its limitations still remain. One shortcoming of the AO is the lack of crucial immune cell components, such as macrophages and neutrophils, that play a key role in the pathological development. This deficiency limits our capacity to model various diseases and subsequent drug screening approaches using AO. Furthermore, detailed understanding of the development of pulmonary disorders and the biological mechanisms how fatal viral infection and environmental toxic materials affect the lungs are remain incompletely understood, which attributed to lack of in vitro human models that recapitulate the architecture and function of alveolar tissue. In this lecture, we discuss the progress and potential applications in AO technology and hPSC-derived macrophages that are particularly relevant to recapitulate pulmonary fibrosis. We also discuss the potential use of in vitro AO platform for evaluating the adverse effects of viral infection and environmental toxins including particulate matter and heavy metals